The issue with interlaced is that in runs at half the refresh rate. It is something currently being looked into. A work around is to disable VSYNC and Audio sync and enable 1.0x max run run speed in throttle options. Yes, this will introduce a small ammount judder and possible tearing vut as tge refresh rate is very close to the original it’s not that bad.
The issue with the .xprofile is new though. It have been working fine for people.
Is it in your home directory?
Can you check what the permissions are for the file? Just right click and choose properties.
Could you paste the contents of the file so I can see if there are any issue?
There is an issue section on the MME4CRT forum. I would appreciate it if you could open this issue here. https://mme4crt.alphanudesign.co.uk/forum/index.php
Yes, MME4CRT does get merged into mainstream RetroArch. However, There can be weeks or even months before merges happen. If you want to stay on the bleeding edge of MME4CRT you’ll want to keep with MME4CRT instead of RA until a merge is announced.