When I play PAL optimized games under a 50Hz modeline I get strange artifacts (not so on near 60Hz modelines). Not core related, I do get them on bsnes-balanced (Asterix, Tintin in Tibet) or Genesis Plus GX (Flink, Alien Soldier).
I was testing with a 50Hz modeline first, then for Sega Genesis I created a new 49.701 modeline. I revisited the 50Hz modeline to conform to LCD standard (CRU preset) but I get these artifacts on blinking sprites or big flat areas (resembles macroblocks, or unresolved h264 bframes). To be sure I disabled the shader and still get it so I recorded a video (link). The modeline works fine with other emulators like PCSX2, but this one is not full exclusive. So any hint on how to resolve it is welcome.