It depends on how resource intensive the core is and game you’re playing.
For me I have an i5 4670k not oc’ed and GTX 770 and spent a good day off going through all the cores I use and obtained a general idea of what my machine can and can’t handle.
Using the OGL backend For example systems up until say PSX my machine can handle GPU hard sync 0, frame delay of 10 and run ahead of 2 frames (could handle even more frames but then the game starts to glitch) Using Game mode on my Plasma and DS4 Bluetooth connnection (4ms polling rate) I can’t tell the difference between my CRT and my Plasma with input lag. After PSX I cannot handle run ahead that well but I can get away with shaving off some lag with frame delay.