In the Windows port of RetroArch I notice a fair amount of input lag compared to other emulators (Mednafen and Kega Fusion are two I tested against) with Vsync on with either of my displays at 60hz. I tried the option to turn off desktop composition since I’ve heard that is supposed to help, but I didn’t notice a difference. Turning off Vsync puts it on par, but that creates too much tearing. At 120hz on my monitor it’s about as low as Mednafen (both emulators with Vsync on), but running at that refresh rate I get stuttering with any emulator I’ve tried.
Nestopia is the only other Windows emulator I’ve ran where the input lag was as noticeable to me.
I’m running Windows 7 64-bit, RetroArch 0.9.9-wip2 and using a Saturn USB pad to test.