Sometimes, a game simply won’t work in one core — for example, certain Saturn games will allow the Mednafen Saturn core to boot, but it will boot to the CD player instead of the game itself. Games that cause this behavior in Mednafen will (usually) boot in Yabuse with no problems, but because the Mednafen Saturn core has technically booted correctly, it’ll be stored as the assigned core for that game in the playlist.
(This also happens if you accidentally select a PSX core instead of a Saturn core. Easily avoidable by assigning cores to playlists via settings as hunterk described, but worth mentioning.)
Currently, the only way to reset them is to manually edit the playlist, changing saved cores back to “DETECT”. Being able to reset/change cores for select games in the menu itself would be a welcomed quality-of-life feature.