Getting CD based games to work

Why will certain CD based games work fine but others cause RA to crash at launch? I noticed that cue/iso format games load fine, but when I tried to load a game in cue/iso/wav or cue/iso/mp3 it doesn’t work. Is there a trick to getting these games to work or do all CD based games need to be in a certain format?

It depends on the core. I think all of them support bin/cue, while genplusgx supports ogg audio…? Dunno if any of the others support compressed audio, but I don’t think so.