Is There A Way To Change DESUME Core settings?

Every time I run the DS Emulator on RetroArch, It always crashes. It also crashes when I try to run DeSmuMe Emulator. However when I noticed that when I changed the desmume.ini for DeSmuMe emulator to:

[Video] Window Rotate=0 Filter=0 Width=256 Height=384 Window Size=0 Window width=256 Window height=384 WindowPosX=0 WindowPosY=0 Display Method=3

It started working smoothly! So I was wondering if there is a way to do the same in RetroArch. Thanks! P.S. The reason why I want RetroArch to run is so I can use the on screen overlay for my Windows 8 Tablet.