Today i installed the latest Avast update (prog + virus definitions). Since then, whenever i start a game in Launchbox which is setup to run under Retroarch, it starts in Paused mode!
I checked the console and i noticed that Retroarch can’t write on the History file (supported by Retroarch 1.41) because it is blocked by Avast.
The solution to this is to run Retroarch As Admin, or to Exclude the Retroarch folder from Avast.