Hi, I recently updated to Win 10 x64 and also installed fresh latest stable RA 1.3.6 x64. There seems to be some problem on mednafenPSX and Desmume cores, every few minutes there is slight stutter for about half second, (audio crack, video stutter) and everything goes back to normal 60fps fluid experience. I have both audio sync and hard gpu sync enabled, default audio settings, v sync ON, 59.950fps, exclusive full screen, gameplay is butter-smooth beside above mentioned, and its input-lag free for my senses. I tried enabling cache ISO to memory on mednafenPSX and cache to memory on desmume core options but rarely stutters still occurs, after this tweak I only encountered this on desmume though.
Specs: Pentium G3460 @ 3.5ghz HD 7770 1GB GDDR5 4GB RAM DDR3 7200rpm HDD SATA 2 500GB
Also tried high performance power plan but no advantage over balanced.