Retroarch Windows wont recognize key binds

I am using retroarch for quite a few different systems and am having problems with key bindings. I can play the game just fine, but it will not recognize the key bindings for the menu overlay, saving, or anything like that. I am using the default function keys for this. Thank you for any help.

As an update. I tried to bind the keys to others key on my keyboard, still nothing. The keys used to play the game work just fine, but no other key/key bindings will work.

Do you have ‘hotkey enable’ bound to anything? If so, it will ignore any hotkey commands unless you hold that key down first.

You might also check unified menu controls.