Only in the graphic chip VIC-II emulation, which in practice does not manifest much in games, but some demos do have issues.
https://vice-emu.sourceforge.io/vice_2.html#SEC7 says
As of version 2.3, two C64 emulators are provided: x64' (fast) and
x64sc’ (accurate). As of version 3.4 `x64’ will no more get built by default and is not contained in the default binary packages.
The fast C64 emulator, called `x64’, features a fairly complete emulation of the VIC-II video chip: sprites, all registers and all video modes are fully emulated. The emulation has been fully cycle-accurate since version 0.13.0.
The accurate C64 emulator, called x64sc', features a cycle-based and pixel-accurate VIC-II emulation. This requires a much faster machine than the old
x64’.