I came here seeking the same info, sorry to bump this old thread. No idea why twinaphex believes his change wasn’t for the worse because the audio in the current core sounds really low quality. That is not how a DS sounds and it’s also not how Desmume standalone sounds either. The audio in the old core was a lot better and clean of clicks, hissing and distortion which plagues the current version.
You need only fire up Radiant Historia to test. There’s a short cutscene near the beginning where a heartbeat plays. On standalone Desmume, it sounds fine. On the current core in RA, it sounds terrible and there’s a loud click after each heartbeat. Music sounds really poor too.
Does anyone happen to have a version of “desmume_libretro.dll” from before August of 2015? The only older version I can find is the archived core from January of last year which is a bit too dated and problematic.