I think this problem started with the recent input changes. My older setup doesn’t have this problem.
I use the guide button on the controller to bring up the RetroArch menu. Which works nicely with all cores since they don’t use this button. The same applied with MAME 2016 but nowadays when i press the guide button it causes random functions that don’t make sense.
First, it brings up MAME volume options. Then it enables player 2,3 and 4. It’s like every time i’m pressing it, something odd happens. Can’t fix it though, it looks like an internal issue. Other cores don’t do that so it’s not a Windows issue, i have disabled this button on Windows.