I noticed a minor bug with multitap support for the Mednafen core. It looks like whenever you activate the multitap for a game, the game will automatically show five controllers (Four from multitap + one from other player input) no matter how many controllers you assign or disable in Retroarch (as far as I can tell at least).
Note that this is different from behavior in stand-alone Mednafen which will show only the four active controllers unless you tell it otherwise.
If I’ve missed a setting somewhere, please let me know!