I don’t know if Lakka includes Cg support for x86/64, but if so, those shaders are currently preferred over the GLSL shaders. There’s no Cg for ARM, though, so any ARM-based devices need to use the GLSL versions.
Mobile GPUs can’t run a lot of the fancier shaders but crt-easymode is relatively lightweight and may work alright on more powerful devices. On Raspberry Pi variants, check out crt-pi, which was written specifically to run full speed on them.
For smoothing shaders, xBR generally looks better and is preferred on x86/64, but again, mobile GPUs can’t often handle it. For those, hqx (e.g., hq2x) are lighter. I don’t know if they’re light enough for RPi, though.
For people who like super-sharp pixels, retro/sharp-bilinear should be fast enough for pretty much anything and will prevent misshapen pixels caused by non-integer nearest-neighbor scaling. The aann and pixellate shaders have similar effects but are slower and may be too slow for mobile GPUs.