Hi there!
If by vertical monitors you mean rotating your real display, I’ve no direct experience, but it should work; there could be unhandled issues tho.
There are none if your display stay 16:9, but you want to emulate 9:16 games on it.
4k is welcome and everything will look better. Also, 9:16 games will benefit from it because you will be able do disable tate mode and have vertical scanlines without moire.