Have you looked some of the videos in the 2 playlists I posted above? I don’t think they look so bad at lower resolutions even though they’re mostly 4K native. They still look better than raw pixels and the scanlines do have an effect which wouldn’t be present if the OP went with a GTU only solution.
Then there are some specific presets in my pack that should look pretty decent even if scaled, especially the CyberLab_Upscaled_No_Border and maybe my RGB Sharp and RGB Smooth presets.
So it really depends. Some settings will look better than others when scaled.
I’ve done some live streaming at 1080p using Intel Quick Sync and it looked pretty decent using Bilinear filtering when up/downscaling. Not native perfect but the scanlines and what was left of the Mask still made a positive impression.
The biggest challenge I think is the bitrate and the Colour format options. If you mess up there, it’s Game Over so you really should avoid streaming over WiFi but I’ve had a relatively positive experience setting up a Retro Streaming System for someone.