S-Video is all about setting artifacting and fringing down to 0.0. If you want stronger filtering with increasing internal resolution of the games, then you can increase the Internal Resolution parameter also. NTSC settings shouldn’t be a major problem. Only these 3 params for start, maybe you can also lower the number of taps, which will also reduce color bleeding.
Interlacing mode is best set to 4.0 or 5.0 for better vertical smoothness.
The challenge, as usual, is setting the mask and mask mitigation settings right for your taste, maybe also contrast and brightness.
I wouldn’t advise to use BLARGG’s + NTSC shaders at the same time though, as the image would get excess filtering, which is not desirable.